acta logo published quarterly by Mattioli 1885

current issue index
Foreword
5. Seymour Reichlin

Introduction
7. Francesco Antonio Manzoli, Roberto Toni, Ronald M. Lechan, Giorgio Sandri, Marco Vitale, Giacomo Azzali

Frontiers in structures and processes of morpho-functional communication in living systems
13. Alexander E. Ermolenko, Elena A. Perepada
The symmetry of man
21. Alexander E. Ermolenko, Elena A. Perepada
The biocrystalloid structure of man: an extracellular theory
26. Giulia Spaletta
Reconstruction in space and visualization of a planar image: a mathematical and computational introduction
32. Alberto Strumia
Complexity seems to open a way towards a new Aristotelian-thomistic ontology
39. Rossella Lupacchini
Finite machines, mental procedures, and modern physics

Modelling in neural and neuroendocrine communication
49. Giulio Giorello, Corrado Sinigaglia
Perception in action
58. Fabio Benfenati
Synaptic plasticity and the neurobiology of learning and memory
67. Roberto Toni, Giulia Spaletta, Claudia Della Casa, Simone Ravera, Giorgio Sandri
Computation and brain processes, with special reference to neuroendocrine systems
84. Ronald M. Lechan, Csaba Fekete
Infundibular tanycytes as modulators of neuroendocrine function: hypothetical role in the regulation of the thyroid and gonadal axis
99. Nicholas E. Simpson, Ioannis Costantinidis
13C NMR isotopomeric analysis and its application in the study of endocrine cell metabolism and function
113. Alberto M. Martelli, Camilla Evangelisti, Anna Maria Billi, Lucia Manzoli, Veronica Papa, Lucio Cocco
Intranuclear 3’-phosphoinositide metabolism and apoptosis protection in PC12 cells

Modelling in endocrine communication
123. Andrew Martorella, Richard Robbins
Serum peptide profiling: identifying novel cancer biomarkers for early disease detection
129. Roberto Toni, Claudia Della Casa, Giulia Spaletta, Giacomo Marchetti, Perseo Mazzoni, Monica Bodria, Simone Ravera, Davide Dallatana, Sergio Castorina, Vincenzo Riccioli, Emilio Giovanni Castorina, Salvatore Antoci, Enrico Campanile, Gabriella Scalise, Raffaella Rossi, Giorgio Ugolotti, Andrew Martorella, Elio Roti, Fiorella Sgallari, Aldo Pinchera
The bioartificial thyroid: a biotechnological perspective in endocrine organ engineering for transplantation replacement
156. Dennis Engler
Hypothesis: Musculin is a hormone secreted by skeletal muscle, the body’s largest endocrine organ. Evidence for actions on the endocrine pancreas to restrain the b-cell mass and to inhibit insulin secretion and on the hypothalamus to co-ordinate the neuroendocrine and appetite responses to exercise
207. Nadir M. Maraldi, Cristina Capanni, Elisabetta Mattioli, Marta Columbaro, Stefano Squarzoni,Weena K. Parnaik, Manfred Wehnert, Giovanna Lattanzi
A pathogenic mechanism leading to partial lipodistrophy and prospects for pharmacological treatment of insulin resistance syndrome
216. L-G Luo, Ivor Jackson
Thyrotropin Releasing Hormone (TRH) may preserve pancreatic islet cell function: potential role in the treatment of diabetes mellitus
222. Giorgio Valenti
Frailty as a dysruption of steroid “syncrinology” in elderly man

Modelling in immune communication
227. Marco Vitale
Time for integration: communication in the immune system
231. Stephen J. Hopkins
Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration
248. Damien T. O’Dwyer, Patrick McElduff, Pärt Peterson, Jaakko Perheentupa, Patricia A. Crock
Pituitary autoantibodies in autoimmune polyendocrinopathy – candidiasis – ectodermal dystrophy (APECED)
255. Ellie Chuang, Mark E. Molitch
Prolactin and autoimmune diseases in humans
262. Mauro Vaccarezza, Giorgio Delbello, Giorgio Zauli
A role of the TRAIL-TRAIL receptor system in the pathogenesis of diabetes

Cover:

Immunocytochemical staining of the cytokine interleukin-1ß (IL-1ß) in neurons of the rat cingulate cortex. Immunostaining was achieved using a rabbit polyclonal antibody (1: 750, from Dr. S. Reichlin) to recombinant rat IL-1ß. At the light microscopic level, intense immunoreactivity (IR) is present in the cell nucleus (dark blue), whereas weaker immunostaining is visible in the neuronal process (light blue). At the ultrastructural level, IL-1ß-IR can be recognized as electrondense material containing 15 nm gold particles (arrow), in the cytoplasm of a dendrite. Note that the dendritic process is sorrounded by unlabeled axon terminals, raising the possibility that synaptic inputs regulate the intracellular distribution and/or extracellular release of IL-1ß in the rat limbic cortex. From Toni R, Della Casa C. Subcellular localization of interleukin 1b in limbic-diencephalic regions of the rat brain. Ital J Anat Embryol 1999; 104 (suppl 2), 73

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